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http://hdl.handle.net/2445/147723
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DC Field | Value | Language |
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dc.contributor.author | Su, Hanxia | - |
dc.contributor.author | Sureda Gómez, Miquel | - |
dc.contributor.author | Rabaneda Lombarte, Neus | - |
dc.contributor.author | Gelabert, Maria | - |
dc.contributor.author | Xie, Jianlei | - |
dc.contributor.author | Wu, Wei | - |
dc.contributor.author | Adell i Creixell, Teresa | - |
dc.date.accessioned | 2020-01-14T09:49:52Z | - |
dc.date.available | 2020-01-14T09:49:52Z | - |
dc.date.issued | 2017-10-04 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.uri | http://hdl.handle.net/2445/147723 | - |
dc.description.abstract | β-Catenin, the core element of the Wnt/β-catenin pathway, is a multifunctional and evolutionarily conserved protein which performs essential roles in a variety of developmental and homeostatic processes. Despite its crucial roles, the mechanisms that control its context-specific functions in time and space remain largely unknown. The Wnt/β-catenin pathway has been extensively studied in planarians, flatworms with the ability to regenerate and remodel the whole body, providing a 'whole animal' developmental framework to approach this question. Here we identify a C-terminally truncated β-catenin (β-catenin4), generated by gene duplication, that is required for planarian photoreceptor cell specification. Our results indicate that the role of β-catenin4 is to modulate the activity of β-catenin1, the planarian β-catenin involved in Wnt signal transduction in the nucleus, mediated by the transcription factor TCF-2. This inhibitory form of β-catenin, expressed in specific cell types, would provide a novel mechanism to modulate nuclear β-catenin signaling levels. Genomic searches and in vitro analysis suggest that the existence of a C-terminally truncated form of β-catenin could be an evolutionarily conserved mechanism to achieve a fine-tuned regulation of Wnt/β-catenin signaling in specific cellular contexts. | - |
dc.format.extent | 32 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pgen.1007030 | - |
dc.relation.ispartof | PLoS Genetics, 2017, vol. 13, num. 10, p. e1007030 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pgen.1007030 | - |
dc.rights | cc-by (c) Su, Hanxia et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Cèl·lules | - |
dc.subject.other | Proteins | - |
dc.subject.other | Cells | - |
dc.title | A C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 673739 | - |
dc.date.updated | 2020-01-14T09:49:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28976975 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
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File | Description | Size | Format | |
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673739.pdf | 9.89 MB | Adobe PDF | View/Open |
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