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dc.contributor.authorSu, Hanxia-
dc.contributor.authorSureda Gómez, Miquel-
dc.contributor.authorRabaneda Lombarte, Neus-
dc.contributor.authorGelabert, Maria-
dc.contributor.authorXie, Jianlei-
dc.contributor.authorWu, Wei-
dc.contributor.authorAdell i Creixell, Teresa-
dc.description.abstractβ-Catenin, the core element of the Wnt/β-catenin pathway, is a multifunctional and evolutionarily conserved protein which performs essential roles in a variety of developmental and homeostatic processes. Despite its crucial roles, the mechanisms that control its context-specific functions in time and space remain largely unknown. The Wnt/β-catenin pathway has been extensively studied in planarians, flatworms with the ability to regenerate and remodel the whole body, providing a 'whole animal' developmental framework to approach this question. Here we identify a C-terminally truncated β-catenin (β-catenin4), generated by gene duplication, that is required for planarian photoreceptor cell specification. Our results indicate that the role of β-catenin4 is to modulate the activity of β-catenin1, the planarian β-catenin involved in Wnt signal transduction in the nucleus, mediated by the transcription factor TCF-2. This inhibitory form of β-catenin, expressed in specific cell types, would provide a novel mechanism to modulate nuclear β-catenin signaling levels. Genomic searches and in vitro analysis suggest that the existence of a C-terminally truncated form of β-catenin could be an evolutionarily conserved mechanism to achieve a fine-tuned regulation of Wnt/β-catenin signaling in specific cellular contexts.-
dc.format.extent32 p.-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofPLoS Genetics, 2017, vol. 13, num. 10, p. e1007030-
dc.rightscc-by (c) Su, Hanxia et al., 2017-
dc.titleA C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians-
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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