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Title: A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility
Author: González Serna, David
Carmona, Elio G.
Ortego Centeno, Norberto
Simeón Aznar, Carmen Pilar
Solans, Roser
Hernández Rodríguez, José
Tolosa Vilella, Carles
Castañeda, Santos
Narváez García, Francisco Javier
Martinez Valle, Ferran
Witte, Torsten
Neumann, Thomas
Holle, Julia
Beretta, Lorenzo
Boiardi, Luigi
Emmi, Giacomo
Cimmino, Marco A.
Vaglio, Augusto
Herrick, Ariane L.
Denton, Christopher P.
Salvarani, Carlo
Cid, María C.
Morgan, Ann W.
Fonseca, Carmen
González-Gay, Miguel A.
Martín, Javier
Márquez, Ana
European GCA Consortium
European Scleroderma Group
Keywords: Genètica molecular
Cèl·lules B
Molecular genetics
B cells
Issue Date: 26-Dec-2018
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells. An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic predisposition to several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Based on the elevated levels of this cytokine found in patients with giant cell arteritis (GCA) and systemic sclerosis (SSc), we aimed to assess whether this functional variant also represents a novel genetic risk factor for these two disorders. METHODS: A total of 1,728 biopsy-proven GCA patients from 4 European cohorts, 4,584 SSc patients from 3 European cohorts and 5,160 ethnically-matched healthy controls were included in the study. The single nucleotide polymorphism (SNP) rs374039502, which colocalizes with the genetic variant previously implicated in autoimmunity, was genotyped using a custom TaqMan assay. First, association analysis was conducted in each independent cohort using χ2 test in Plink (v1.9). Subsequently, different case/control sets were meta-analyzed by the inverse variance method. RESULTS: No statistically significant differences were found when allele distributions were compared between cases and controls for any of the analyzed cohorts. Similarly, combined analysis of the different sets evidenced a lack of association of the rs374039502 variant with GCA (P = 0.421; OR (95% CI) = 0.92 (0.75-1.13)) and SSc (P = 0.500; OR (95% CI) = 1.05 (0.91-1.22)). The stratified analysis considering the main clinical subphenotypes of these diseases yielded similar negative results. CONCLUSION: Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc.
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It is part of: PLoS One, 2018, vol. 13, num. 12, p. e0209343
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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