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http://hdl.handle.net/2445/148241
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DC Field | Value | Language |
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dc.contributor.author | Verdolini, Norma | - |
dc.contributor.author | Perugi, Giulio | - |
dc.contributor.author | Samalin, Ludovic | - |
dc.contributor.author | Murru, Andrea | - |
dc.contributor.author | Angst, Jules | - |
dc.contributor.author | Azorin, Jean-Michel | - |
dc.contributor.author | Bowden, Charles L. | - |
dc.contributor.author | Mosolov, Sergey | - |
dc.contributor.author | Young, Allan H. | - |
dc.contributor.author | Barbuti, Margherita | - |
dc.contributor.author | Guiso, Giovanni | - |
dc.contributor.author | Popovic, Dina | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.contributor.author | Pacchiarotti, Isabella | - |
dc.contributor.author | BRIDGE-II-Mix Study Group | - |
dc.date.accessioned | 2020-01-20T14:54:33Z | - |
dc.date.available | 2020-01-20T14:54:33Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0001-690X | - |
dc.identifier.uri | http://hdl.handle.net/2445/148241 | - |
dc.description.abstract | OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study. METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed. RESULTS: MDE-A group was more frequently associated with BD (P < 0.001), while aggressiveness was negatively correlated with unipolar depression (P < 0.001). At the logistic regression, aggressiveness was associated with the age at first depressive episode (P < 0.001); the severity of mania (P = 0.03); the diagnosis of BD (P = 0.001); comorbid borderline personality disorder (BPD) (P < 0.001) but not substance abuse (P = 0.63); no current psychiatric treatment (P < 0.001); psychotic symptoms (P = 0.007); the marked social/occupational impairment (P = 0.002). The variable most significantly associated with aggressiveness was the presence of DSM-5 mixed features (P < 0.001, OR = 3.815). After the exclusion of BPD, the variable of lifetime suicide attempts became significant (P = 0.013, OR = 1.405). CONCLUSION: Aggressiveness seems to be significantly associated with bipolar spectrum disorders, independently from BPD and substance abuse. Aggressiveness should be considered as a diagnostic criterion for the mixed features specifier and a target of tailored treatment strategy. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/acps.12777 | - |
dc.relation.ispartof | Acta Psychiatrica Scandinavica, 2017, vol. 136, num. 4, p. 362-372 | - |
dc.relation.uri | https://doi.org/10.1111/acps.12777 | - |
dc.rights | (c) John Wiley & Sons, 2017 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Depressió psíquica | - |
dc.subject.classification | Agressivitat | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Mental depression | - |
dc.subject.other | Aggressiveness | - |
dc.title | Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 673076 | - |
dc.date.updated | 2020-01-20T14:54:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28741646 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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673076.pdf | 173.62 kB | Adobe PDF | View/Open |
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