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Title: EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study
Author: Martín Cardona, Albert
Fernández Esparrach, Glòria
Subtil, J. C.
Iglesias García, J.
García Guix, Marta
Barturen Barroso, A.
Gimeno García, A. Z.
Esteban, J. M.
Pardo Balteiro, A.
Velasco Guardado, A.
Vázquez-Sequeiros, Enrique
Loras Alastruey, Carme
Martínez Moreno, B.
Castellot, A.
Huertas, Carlos
Martínez Lapiedra, M.
Sánchez Yagüe, Andrés
Terán, A.
Morales Alvarado, Víctor Jair
Betes, M.
Iglesia, D. de la
Sánchez Montes, Cristina
Lozano, Maria Dolores
Lariño Noia, J.
Ginés, A.
Tebé, Cristian
Gornals Soler, Joan B.
Spanish Group for EUS-Guided TA in the adrenal gland
Keywords: Diagnòstic
Issue Date: 6-Jun-2019
Publisher: Public Library of Science (PLoS)
Abstract: Background: There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy. Methods: This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy. Results: A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape. Conclusions: EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model.
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It is part of: PLoS One, 2019, vol. 14, num. 6, p. e0216658
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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