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Title: Mediterranean dietary pattern is associated to low risk of aggressive prostate cancer: MCC-Spain study.
Author: Castelló, Adela
Boldo, Elena
Amiano, Pilar
Castaño-Vinyals, Gemma
Aragonés, Nuria
Gómez Acebo, Inés
Peiró Pérez, Rosana
Jiménez Moleón, José Juan
Alguacil, Juan
Tardón, Adonina
Cecchini, Lluís
Lope, Virginia
Dierssen Sotos, Trinidad
Mengual Brichs, Lourdes
Kogevinas, Manolis
Pollán, Marina
Pérez Gómez, Beatriz
Keywords: Dieta
Cuina mediterrània
Càncer de pròstata
Medicina preventiva
Mediterranean cooking
Prostate cancer
Preventive medicine
Issue Date: 1-Feb-2018
Publisher: Elsevier B.V.
Abstract: Purpose: We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. Materials and Methods: MCC-Spain (Multicase-Control Study on Common Tumors in Spain) is a population based, multicase-control study that was done in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiological and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1,277 controls 38 to 85 years old. Three previously identified dietary patterns, including Western, prudent and Mediterranean, were reconstructed using MCC-Spain data. The association of each pattern with prostate cancer risk was assessed by logistic regression models with random, province specific intercepts. Risk according to tumor aggressiveness (Gleason score 6 vs greater than 6) and extension (cT1-cT2a vs cT2b-cT4) was evaluated by multinomial regression models. Results: High adherence to a Mediterranean dietary pattern rich not only in fruits and vegetables but also in fish, legumes and olive oil was specifically associated with a lower risk of Gleason score greater than 6 prostate cancer (quartile 3 vs 1 relative RR 0.66, 95% CI 0.46-0.96 and quartile 4 vs 1 relative RR 0.68, 95% CI 0.46-1.01, p-trend = 0.023) or with higher clinical stage (cT2b-T4 quartile 4 vs 1 relative RR 0.49, 95% CI 0.25-0.96, p-trend = 0.024). This association was not observed with the prudent pattern, which combines vegetables and fruits with low fat dairy products, whole grains and juices. The Western pattern did not show any association with prostate cancer risk. Conclusions: Nutritional recommendations for prostate cancer prevention should consider whole dietary patterns instead of individual foods. We found important differences between the Mediterranean dietary pattern, which was associated with a lower risk of aggressive prostate cancer, and Western and prudent dietary patterns, which had no relationship with prostate cancer risk.
Note: Versió postprint del document publicat a:
It is part of: Journal of Urology, 2018, vol. 199, num. 2, p. 430-437
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ISSN: 0022-5347
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (ISGlobal)

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