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Title: Circulating sex hormone binding globulin: an integrating biomarker for an adverse cardio-metabolic profile in obese pregnant women
Author: Xargay i Torrent, Sílvia
Carreras Badosa, Gemma
Prats Puig, Anna
Soriano, Pilar
Álvarez Castaño, Elena
Ferri, María José
Borrat Padrosa, Sara
Zegher, Francis de
Ibáñez Toda, Lourdes
López Bermejo, Abel
Bassols, Judit
Keywords: Hormones sexuals
Marcadors bioquímics
Sex hormones
Biochemical markers
Pregnant women
Issue Date: 15-Oct-2018
Publisher: Public Library of Science (PLoS)
Abstract: Sex hormone-binding globulin (SHBG) negatively associates with pre-gestational body mass index (BMI) and gestational weight gain. The link with other cardio-metabolic risk factors in pregnant women is poorly understood. Our aim was to study the association of SHBG levels with common cardio-metabolic risk parameters in pregnant woman. Serum SHBG was quantified in 291 Caucasian pregnant women (142 with normal weight, 42 with pregestational obesity, 50 with gestational obesity and 57 with pregestational plus gestational obesity) with uncomplicated pregnancies and parturition. Cardio-metabolic [C-reactive protein (CRP), blood pressure (BP), glycosylated hemoglobin (HbAc1), glucose, C-peptide, insulin, triglycerides and high molecular weight (HMW) adiponectin], and endocrine [testosterone and estradiol] parameters were also assessed. SHBG was negatively correlated with BMI, but also with CRP, BP, HbAc1, pre and post-load glucose, C-peptide, HOMA-IR, triglycerides; and positively with HMW adiponectin (all p<0.01 to p<0.0001). These associations were more robust in women with pregestational plus gestational obesity, who had lower SHBG, in comparison to normal-weight women (p<0.0001). In multivariate analyses in women with pregestational plus gestational obesity SHBG showed independent associations with CRP (β = -0.352, p = 0.03, R2 = 8.0%), DBP (β = -0.353, p = 0.03, R2 = 7.0%) and SBP (β = -0.333, p = 0.04, R2 = 6.0%) independently of BMI and metabolic and endocrine parameters. SHBG is decreased in pregnant women with pregestational plus gestational obesity in association with common cardio-metabolic parameters. SHBG could represent an integrating biomarker for an adverse cardio-metabolic profile in pregnant women with pregestational plus gestational obesity.
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It is part of: PLoS One, 2018, vol. 13, num. 10, p. e0205592
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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