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DC Field | Value | Language |
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dc.contributor.author | Reynés-Llompart, Gabriel | - |
dc.contributor.author | Gámez Cenzano, Cristina | - |
dc.contributor.author | Vercher Conejero, José Luís | - |
dc.contributor.author | Sabaté Llobera, Aida | - |
dc.contributor.author | Calvo Malvar, Nahúm | - |
dc.contributor.author | Martí-Climent, Josep M. | - |
dc.date.accessioned | 2020-01-31T12:28:59Z | - |
dc.date.available | 2020-01-31T12:28:59Z | - |
dc.date.issued | 2018-06-08 | - |
dc.identifier.issn | 0094-2405 | - |
dc.identifier.uri | http://hdl.handle.net/2445/149147 | - |
dc.description.abstract | INTRODUCTION: The aim of this study was to evaluate the behavior of a penalized-likelihood image reconstruction method (Q.Clear) under different count statistics and lesion-to-background ratios (LBR) on a BGO scanner, in order to obtain an optimum penalization factor (β value) to study and optimize for different acquisition protocols and clinical goals. METHODS: Both phantom and patient images were evaluated. Data from an image quality phantom were acquired using different Lesion-to-Background ratios and acquisition times. Then, each series of the phantom was reconstructed using β values between 50 and 500, at intervals of 50. Hot and cold contrasts were obtained, as well as background variability and contrast-to-noise ratio (CNR). Fifteen 18 F-FDG patients (five brain scans and 10 torso acquisitions) were acquired and reconstructed using the same β values as in the phantom reconstructions. From each lesion in the torso acquisition, noise, contrast, and signal-to-noise ratio (SNR) were computed. Image quality was assessed by two different nuclear medicine physicians. Additionally, the behaviors of 12 different textural indices were studied over 20 different lesions. RESULTS: Q.Clear quantification and optimization in patient studies depends on the activity concentration as well as on the lesion size. In the studied range, an increase on β is translated in a decrease in lesion contrast and noise. The net product is an overall increase in the SNR, presenting a tendency to a steady value similar to the CNR in phantom data. As the activity concentration or the sphere size increase the optimal β increases, similar results are obtained from clinical data. From the subjective quality assessment, the optimal β value for torso scans is in a range between 300 and 400, and from 100 to 200 for brain scans. For the recommended torso β values, texture indices present coefficients of variation below 10%. CONCLUSIONS: Our phantom and patients demonstrate that improvement of CNR and SNR of Q.Clear algorithm which depends on the studied conditions and the penalization factor. Using the Q.Clear reconstruction algorithm in a BGO scanner, a β value of 350 and 200 appears to be the optimal value for 18F-FDG oncology and brain PET/CT, respectively. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association of Physicists in Medicine | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/mp.12986 | - |
dc.relation.ispartof | Medical Physics, 2018, vol. 45, num. 7, p. 3214-3222 | - |
dc.relation.uri | https://doi.org/10.1002/mp.12986 | - |
dc.rights | (c) American Association of Physicists in Medicine, 2018 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Tomografia per emissió de positrons | - |
dc.subject.classification | Tomografia computada per emissió de fotó simple | - |
dc.subject.classification | Imatges mèdiques | - |
dc.subject.other | Positron emission tomography | - |
dc.subject.other | Single-photon emission computed tomography | - |
dc.subject.other | Imaging systems in medicine | - |
dc.title | Phantom, clinical, and texture indices evaluation and optimization of a penalized-likelihood image reconstruction method (Q.Clear) on a BGO PET/CT scanner | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687560 | - |
dc.date.updated | 2020-01-31T12:28:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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687560.pdf | 683.47 kB | Adobe PDF | View/Open |
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