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Title: VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
Author: Fonseca, Ana Maria
González, Raquel
Bardají, Azucena
Jairoce, Chenjerai
Rupérez, María
Jiménez, Alfons
Quintó, Llorenç
Cisteró, Pau
Vala, Anifa
Sacoor, Charfudin
Gupta, Himanshu
Hegewisch-Taylor, Jennifer
Brew, Joe
Ndam, Nicaise Tuikue
Kariuki, Simon
López, Marta
Dobaño, Carlota, 1969-
Chitnis, Chetan E.
Ouma, Peter
Ramharter, Michael
Abdulla, Salim
Aponte, John J.
Massougbodji, Achille
Briand, Valerie
Mombo-Ngoma, Ghyslain
Desai, Meghna
Cot, Michel
Nhacolo, Arsénio
Sevene, Esperança Júlia Pires
Macete, Eusebio Víctor
Menéndez, Clara
Mayor Aparicio, Alfredo Gabriel
Keywords: Serologia
Plasmodium falciparum
Plasmodium falciparum
Issue Date: Oct-2019
Publisher: Centers for Disease Control and Prevention
Abstract: Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.
Note: Reproducció del document publicat a:
It is part of: Emerging Infectious Diseases, 2019, vol. 25, num. 10, p. 1851-1860
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ISSN: 1080-6040
Appears in Collections:Articles publicats en revistes (ISGlobal)

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