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http://hdl.handle.net/2445/149433
Title: | Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of aterosclerosis progression in ApoE-deficient mice |
Author: | Hueso Val, Miguel Ramon, Laura de Navarro, Estanis Ripoll Llagostera, Èlia Cruzado, Josep Ma. Grinyó Boira, Josep M. Torras Ambròs, Joan |
Keywords: | RNA Macròfags Aterosclerosi Ratolins (Animals de laboratori) RNA Macrophages Atherosclerosis Mice (Laboratory animals) |
Issue Date: | Dec-2016 |
Publisher: | Elsevier |
Abstract: | Data presented in this Data in Brief article correspond to the article 'in vivo' silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis' (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.dib.2016.11.045 |
It is part of: | Data in Brief, 2016, vol. 9, p. 1105-1112 |
URI: | http://hdl.handle.net/2445/149433 |
Related resource: | https://doi.org/10.1016/j.dib.2016.11.045 |
ISSN: | 2352-3409 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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