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Title: Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of aterosclerosis progression in ApoE-deficient mice
Author: Hueso Val, Miguel
Ramon, Laura de
Navarro, Estanis
Ripoll Llagostera, Èlia
Cruzado, Josep Ma.
Grinyó Boira, Josep M.
Torras Ambròs, Joan
Keywords: RNA
Ratolins (Animals de laboratori)
Mice (Laboratory animals)
Issue Date: Dec-2016
Publisher: Elsevier
Abstract: Data presented in this Data in Brief article correspond to the article 'in vivo' silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis' (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing.
Note: Reproducció del document publicat a:
It is part of: Data in Brief, 2016, vol. 9, p. 1105-1112
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ISSN: 2352-3409
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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