Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/149518
Title: Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
Author: Cabib, Christopher
Llufriu Duran, Sara
Martínez-Heras, Eloy
Saiz Hinajeros, Albert
Valls Solé, Josep
Keywords: Esclerosi múltiple
Neurofisiologia
Multiple sclerosis
Neurophysiology
Issue Date: 1-Aug-2014
Publisher: Public Library of Science (PLoS)
Abstract: Brain lesions in patients with multiple sclerosis may lead to abnormal excitability of brainstem reflex circuits because of impairment of descending control pathways. We hypothesized that such abnormality should show in the analysis of blink reflex responses in the form of asymmetries in response size. The study was done in 20 patients with relapsing-remitting multiple sclerosis and 12 matched healthy subjects. We identified first patients with latency abnormalities (AbLat). Then, we analyzed response size by calculating the R2c/R2 ratio to stimulation of either side and the mean area of the R2 responses obtained in the same side. Patients with significantly larger response size with respect to healthy subjects in at least one side were considered to have abnormal response excitability (AbEx). We also examined the blink reflex excitability recovery (BRER) and prepulse inhibition (BRIP) of either side in search for additional indices of asymmetry in response excitability. Neurophysiological data were correlated with MRI-determined brain lesion-load and volume. Eight patients were identified as AbLat (median Expanded Disability Status Scale-EDSS = 2.75) and 7 of them had ponto-medullary lesions. Nine patients were identified as AbEx (EDSS = 1.5) and only 2 of them, who also were AbLat, had ponto-medullary lesions. In AbEx patients, the abnormalities in response size were confined to one side, with a similar tendency in most variables (significantly asymmetric R1 amplitude, BRER index and BRIP percentage). AbEx patients had asymmetric distribution of hemispheral lesions, in contrast with the symmetric pattern observed in AbLat. The brainstem lesion load was significantly lower in AbEx than in AbLat patients (p = 0.04). Asymmetric abnormalities in blink reflex response excitability in patients with multiple sclerosis are associated with lesser disability and lower tissue loss than abnormalities in response latency. Testing response excitability could provide a reliable neurophysiological index of dysfunction in early stages of multiple sclerosis.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0103897
It is part of: PLoS One, 2014, vol. 9, num. 8, p. e103897
URI: http://hdl.handle.net/2445/149518
Related resource: https://doi.org/10.1371/journal.pone.0103897
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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