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http://hdl.handle.net/2445/149576
Title: | Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer |
Author: | Blasco-Benito, Sandra Moreno Guillén, Estefanía Seijo-Vila, Marta Tundidor, Isabel Andradas, Clara Caffarel, María M. Caro-Villalobos, Miriam Urigüen, Leyre Diez-Alarcia, Rebeca Moreno-Bueno, Gema Hernández, Lucía Manso, Luis Homar Ruano, Patricia C. McCormick, Peter J. Bibic, Lucka Bernadó Morales, Cristina Arribas, Joaquín V. (Vicente) Canals Buj, Meritxell Casadó, Vicent Canela Campos, Enric I. Guzmán, Manuel Pérez-Gómez, Eduardo Sánchez Mora, Cristina |
Keywords: | Càncer de mama Breast cancer |
Issue Date: | 26-Feb-2019 |
Publisher: | National Academy of Sciences |
Abstract: | There is a subtype of breast cancer characterized by the overexpression of the oncogene HER2. Although most patients with this diagnosis benefit from HER2-targeted treatments, some do not respond to these therapies and others develop resistance with time. New tools are therefore warranted for the treatment of this patient population, and for early identification of those individuals at a higher risk of developing innate or acquired resistance to current treatments. Here, we show that HER2 forms heteromer complexes with the cannabinoid receptor CB2R, the expression of these structures correlates with poor patient prognosis, and their disruption promotes antitumor responses. Collectively, our results support HER2-CB2R heteromers as new therapeutic targets and prognostic tools in HER2+ breast cancer |
Note: | Reproducció del document publicat a: https://doi.org/10.1073/pnas.1815034116 |
It is part of: | Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2019, vol. 116, num. 9, p. 3863-3872 |
URI: | http://hdl.handle.net/2445/149576 |
Related resource: | https://doi.org/10.1073/pnas.1815034116 |
ISSN: | 0027-8424 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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File | Description | Size | Format | |
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685639.pdf | 2.52 MB | Adobe PDF | View/Open |
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