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http://hdl.handle.net/2445/150092
Title: | Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives |
Author: | Alho, Daniela P.S. Salvador, Jorge A.R. Cascante i Serratosa, Marta Marín Martínez, Silvia |
Keywords: | Apoptosi Càncer Apoptosis Cancer |
Issue Date: | 20-Feb-2019 |
Publisher: | MDPI |
Abstract: | A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules24040766 |
It is part of: | Molecules, 2019, vol. 24, num. 4, p. 766 |
URI: | http://hdl.handle.net/2445/150092 |
Related resource: | https://doi.org/10.3390/molecules24040766 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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