Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/150092
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alho, Daniela P.S. | - |
dc.contributor.author | Salvador, Jorge A.R. | - |
dc.contributor.author | Cascante i Serratosa, Marta | - |
dc.contributor.author | Marín Martínez, Silvia | - |
dc.date.accessioned | 2020-02-12T18:59:56Z | - |
dc.date.available | 2020-02-12T18:59:56Z | - |
dc.date.issued | 2019-02-20 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/150092 | - |
dc.description.abstract | A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways. | - |
dc.format.extent | 21 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/molecules24040766 | - |
dc.relation.ispartof | Molecules, 2019, vol. 24, num. 4, p. 766 | - |
dc.relation.uri | https://doi.org/10.3390/molecules24040766 | - |
dc.rights | cc-by (c) Alho, Daniela P.S. et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | Cancer | - |
dc.title | Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687261 | - |
dc.date.updated | 2020-02-12T18:59:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
687261.pdf | 3.2 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License