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DC Field | Value | Language |
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dc.contributor.author | Balaceanu, Alexandra | - |
dc.contributor.author | Buitrago Ospina, Diana Camila | - |
dc.contributor.author | Walther, Jürgen | - |
dc.contributor.author | Hospital, Adam | - |
dc.contributor.author | Dans, Pablo D. | - |
dc.contributor.author | Orozco López, Modesto | - |
dc.date.accessioned | 2020-02-13T19:05:26Z | - |
dc.date.available | 2020-02-13T19:05:26Z | - |
dc.date.issued | 2019-04-08 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/2445/150222 | - |
dc.description.abstract | We used extensive molecular dynamics simulations to study the structural and dynamic properties of the central d(TpA) step in the highly polymorphic d(CpTpApG) tetranucleotide. Contrary to the assumption of the dinucleotide-model and its nearest neighbours (tetranucleotide-model), the properties of the central d(TpA) step change quite significantly dependent on the next-to-nearest (hexanucleotide) sequence context and in a few cases are modulated by even remote neighbours (beyond next-to-nearest from the central TpA). Our results highlight the existence of previously undescribed dynamical mechanisms for the transmission of structural information into the DNA and demonstrate the existence of certain sequences with special physical properties that can impact on the global DNA structure and dynamics. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkz255 | - |
dc.relation.ispartof | Nucleic Acids Research, 2019, vol. 47, num. 9, p. 4418-4430 | - |
dc.relation.uri | https://doi.org/10.1093/nar/gkz255 | - |
dc.rights | cc-by-nc (c) Balaceanu, Alexandra et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Gene expression | - |
dc.title | Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690232 | - |
dc.date.updated | 2020-02-13T19:05:26Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/823830/EU//BioExcel-2 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30957854 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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690232.pdf | 7.7 MB | Adobe PDF | View/Open |
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