Please use this identifier to cite or link to this item:
Title: Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
Author: López González, Irene
Garcia Esparcia, Paula
Llorens Torres, Franc
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Malaltia d'Alzheimer
Malaltia de Creutzfeldt-Jakob
Malaltia de Parkinson
Alzheimer's disease
Creutzfeldt-Jakob disease
Parkinson's disease
Issue Date: 4-Feb-2016
Publisher: MDPI
Abstract: Polymorphisms in certain inflammatory-related genes have been identified as putative differential risk factors of neurodegenerative diseases with abnormal protein aggregates, such as sporadic Alzheimer's disease (AD) and sporadic Parkinson's disease (sPD). Gene expression studies of cytokines and mediators of the immune response have been made in post-mortem human brain samples in AD, sPD, sporadic Creutzfeldt-Jakob disease (sCJD) subtypes MM1 and VV2, Pick's disease (PiD), progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration linked to mutation P301L in MAPT Frontotemporal lobar degeneration-tau (FTLD-tau). The studies have disclosed variable gene regulation which is: (1) disease-dependent in the frontal cortex area 8 in AD, sPD, sCJD MM1 and VV2, PiD, PSP and FTLD-tau; (2) region-dependent as seen when comparing the entorhinal cortex, orbitofrontal cortex, and frontal cortex area 8 (FC) in AD; the substantia nigra, putamen, FC, and angular gyrus in PD, as well as the FC and cerebellum in sCJD; (3) genotype-dependent as seen considering sCJD MM1 and VV2; and (4) stage-dependent as seen in AD at different stages of disease progression. These observations show that regulation of inflammation is much more complicated and diverse than currently understood, and that new therapeutic approaches must be designed in order to selectively act on specific targets in particular diseases and at different time points of disease progression. Keywords: inflammation; microglia; cytokines; complement; toll-like receptors; chemokines; Alzheimer's disease; Parkinson's disease; Creutzfeldt-Jakob's disease; tauopathies
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2016, vol. 17, num. 2, p. 206
Related resource:
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
667084.pdf1.01 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons