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http://hdl.handle.net/2445/151262
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DC Field | Value | Language |
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dc.contributor.author | Benabou Zdaou, Sanae | - |
dc.contributor.author | Eritja i Casadellà, Ramon | - |
dc.contributor.author | Gargallo Gómez, Raimundo | - |
dc.date.accessioned | 2020-02-26T16:53:30Z | - |
dc.date.available | 2020-02-26T16:53:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2090-7729 | - |
dc.identifier.uri | http://hdl.handle.net/2445/151262 | - |
dc.description.abstract | The conformational equilibria of a guanine-rich sequence found at the promoter region of the human c-kit oncogene are studied by means of circular dichroism spectroscopy (CD) and variable-temperature Size Exclusion Chromatography (SEC). It is shown that the wild sequence ckit21 exists as a mixture of monomeric and multimeric G-quadruplex. Appropriate mutation of several bases in the wild sequence produces the shift from parallel to antiparallel G-quadruplex, as well as the disappearance of multimeric species. The shift from the antiparallel to the parallel conformation induced by temperature is reflected in both CD and SEC profiles. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Hindawi | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1155/2013/631875 | - |
dc.relation.ispartof | ISRN Biochemistry, 2013, vol. 2013, p. 1-7 | - |
dc.relation.uri | https://doi.org/10.1155/2013/631875 | - |
dc.rights | cc-by (c) Benabou Zdaou, Sanae et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.classification | G-estructures | - |
dc.subject.classification | Oligonucleòtids | - |
dc.subject.other | Nucleic acids | - |
dc.subject.other | G-structures | - |
dc.subject.other | Oligonucleotides | - |
dc.title | Variable-temperature size exclusion chromatography for the study of the structural changes in G-quadruplex | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 628444 | - |
dc.date.updated | 2020-02-26T16:53:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25937962 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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628444.pdf | 1.79 MB | Adobe PDF | View/Open |
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