Please use this identifier to cite or link to this item:
Title: Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning
Author: Buitrago Ospina, Diana Camila
Codó Tarraubella, Laia
Illa Pujagut, Ricard
Jorge, Pau de
Flores Guri, Oscar
Battistini, Federica
Bayarri, Genís
Royo, Romina
Del Pino, Marc
Heath, Simon C.
Hospital, Adam
Gelpí Buchaca, Josep Lluís
Brun Heath, Isabelle
Orozco López, Modesto
Keywords: Cromatina
Issue Date: 31-Aug-2019
Publisher: Oxford University Press
Abstract: We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models.
Note: Reproducció del document publicat a:
It is part of: Nucleic Acids Research, 2019, vol. 47, p. 9511-9523
Related resource:
ISSN: 0305-1048
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
692031.pdf4.45 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons