Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/151347
Title: | Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning |
Author: | Buitrago Ospina, Diana Camila Codó Tarraubella, Laia Illa Pujagut, Ricard Jorge, Pau de Flores Guri, Oscar Battistini, Federica Bayarri, Genís Royo, Romina Del Pino, Marc Heath, Simon C. Hospital, Adam Gelpí Buchaca, Josep Lluís Brun Heath, Isabelle Orozco López, Modesto |
Keywords: | Cromatina Bioinformàtica Chromatin Bioinformatics |
Issue Date: | 31-Aug-2019 |
Publisher: | Oxford University Press |
Abstract: | We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkz759 |
It is part of: | Nucleic Acids Research, 2019, vol. 47, p. 9511-9523 |
URI: | http://hdl.handle.net/2445/151347 |
Related resource: | https://doi.org/10.1093/nar/gkz759 |
ISSN: | 0305-1048 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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692031.pdf | 4.45 MB | Adobe PDF | View/Open |
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