Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/151737
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDobaño, Carlota, 1969--
dc.contributor.authorBardají, Azucena-
dc.contributor.authorArévalo Herrera, Myriam-
dc.contributor.authorMartínez Espinosa, Flor E.-
dc.contributor.authorBotto Menezes, Camila-
dc.contributor.authorPadilla, Norma-
dc.contributor.authorMenegon, Michela-
dc.contributor.authorKochar, Swati-
dc.contributor.authorKochar, Sanjay K.-
dc.contributor.authorUnger, Holger Werner-
dc.contributor.authorOme-Kaius, Maria-
dc.contributor.authorRosanas Urgell, Anna-
dc.contributor.authorMalheiros, Adriana-
dc.contributor.authorCastellanos, Maria Eugenia-
dc.contributor.authorHans, Dhiraj-
dc.contributor.authorDesai, Meghna-
dc.contributor.authorCasellas, Aina-
dc.contributor.authorChitnis, Chetan E.-
dc.contributor.authorSeverini, Carlo-
dc.contributor.authorMueller, Ivo-
dc.contributor.authorRogerson, Stephen John-
dc.contributor.authorMenéndez, Clara-
dc.contributor.authorRequena, Pilar-
dc.coverage.spatialGuatemala-
dc.coverage.spatialColombia-
dc.coverage.spatialBrazil-
dc.coverage.spatialIndia-
dc.coverage.spatialPapua New Guinea-
dc.coverage.temporalstart=2008-06; end=2011-10-
dc.date.accessioned2020-03-02T22:19:05Z-
dc.date.available2020-03-02T22:19:05Z-
dc.date.issued2020-03-02-
dc.identifier.urihttp://hdl.handle.net/2445/151737-
dc.descriptionDades primàries associades a l'article publicat a Plos Neglected Tropical Diseases, vol. 14, num. 5, p. e0008155 [https://doi.org/10.1371/journal.pntd.0008155]-
dc.description.abstractPlasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and delivery (periphery, cord and placenta), allowing a longitudinal analysis. At recruitment, we found that P. vivax–infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or mediator in this condition.ca
dc.format.mimetypetext/csv-
dc.format.mimetypetext/html-
dc.language.isoengca
dc.relation.urihttp://hdl.handle.net/2445/173927-
dc.rightscc-by (c) Dobaño et al., 2020-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceDades - Recerca-
dc.subject.classificationPlasmodium vivaxcat
dc.subject.classificationMalàriacat
dc.subject.classificationEmbaràscat
dc.subject.classificationCitoquines-
dc.subject.otherMalariaeng
dc.subject.otherPregnancyeng
dc.subject.otherCytokineseng
dc.titleCytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes (Raw Data)ca
dc.typeinfo:eu-repo/semantics/datasetca
dc.typeinfo:eu-repo/semantics/other-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
Appears in Collections:Dades - Recerca
Dades (ISGlobal)

Files in This Item:
File Description SizeFormat 
cytokines.csvData654.44 kBUnknownView/Open
cytokines.htmlData Dictionary12.54 kBHTMLView/Open
master.csvData48.08 kBUnknownView/Open
master.htmlData Dictionary6.71 kBHTMLView/Open


This item is licensed under a Creative Commons License Creative Commons