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http://hdl.handle.net/2445/151831| Title: | Synthesis and prelimnary biological evaluation of 1,3,5-triazine amino acid derivatives to study their MAO inhibitors |
| Author: | Khattab, Sherine N. Khalil, Hosam H. Bekhit, Adnan A. Mokbel Abd El-Rahman, Mohamed Ayman El-Faham, Ayman Albericio Palomera, Fernando |
| Keywords: | Aminoàcids Hormones Amino acids Hormones |
| Issue Date: | 2-Sep-2015 |
| Publisher: | MDPI |
| Abstract: | Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules200915976 |
| It is part of: | Molecules, 2015, vol. 20, num. 9, p. 15976-15988 |
| URI: | http://hdl.handle.net/2445/151831 |
| Related resource: | https://doi.org/10.3390/molecules200915976 |
| ISSN: | 1420-3049 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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|---|---|---|---|---|
| 666975.pdf | 786.8 kB | Adobe PDF | View/Open |
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