Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/152112
Title: Evaluating the Oxidative Stress in Inflammation: Role of Melatonin
Author: Sánchez, Aroha B.
Calpena Campmany, Ana Cristina
Clares, Beatriz
Keywords: Malalties cròniques
Inflamació
Estrès oxidatiu
Antioxidants
Chronic diseases
Inflammation
Oxidative stress
Antioxidants
Issue Date: 27-Jul-2015
Publisher: MDPI
Abstract: Oxygen is used by eukaryotic cells for metabolic transformations and energy production in mitochondria. Under physiological conditions, there is a constant endogenous production of intermediates of reactive oxygen (ROI) and nitrogen species (RNI) that interact as signaling molecules in physiological mechanisms. When these species are not eliminated by antioxidants or are produced in excess, oxidative stress arises. Oxidative stress can damage proteins, lipids, DNA, and organelles. It is a process directly linked to inflammation; in fact, inflammatory cells secrete a large number of cytokines and chemokines responsible for the production of ROI and RNI in phagocytic and nonphagocytic cells through the activation of protein kinases signaling. Currently, there is a wide variety of diseases capable of producing inflammatory manifestations. While, in the short term, most of these diseases are not fatal they have a major impact on life quality. Since there is a direct relationship between chronic inflammation and many emerging disorders like cancer, oral diseases, kidney diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of this review is to describe the use and role of melatonin, a hormone secreted by the pineal gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant.
Note: Reproducció del document publicat a: https://doi.org/10.3390/ijms160816981
It is part of: International Journal of Molecular Sciences, 2015, vol. 16, num. 8, p. 16981-17004
URI: http://hdl.handle.net/2445/152112
Related resource: https://doi.org/10.3390/ijms160816981
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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