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Title: Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
Author: Muñoz, Patricia
Kestler, Martha
Alarcón, Aristides de
Miró Meda, José M.
Bermejo, Javier
Rodríguez-Abella, Hugo
Fariñas, María Carmen
Cobo Belaustegui, Manuel
Mestres Lucio, Carlos-Alberto
Llinares, Pedro
Goenaga Sánchez, Miguel Ángel
Navas Pérez, Enrique
Oteo, José Antonio
Tarabini Paola
Bouza, Emilio
Moreno Camacho, Ma. Asunción
Sitges Carreño, Marta
Keywords: Endocarditis
Malalties infeccioses
Communicable diseases
Issue Date: Oct-2015
Publisher: Lippincott, Williams & Wilkins. Wolters Kluwer Health
Abstract: Abstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.
Note: Reproducció del document publicat a:
It is part of: Medicine, 2015, vol. 94, num. 43, p. e1816
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ISSN: 0025-7974
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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