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|Title:||Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol|
|Author:||Crippa, Jose Alexandre|
Crippa, Ana C.S.
Hallak, Jaime E.C.
Martín-Santos Laffon, Rocío
Zuardi, Antonio W.
Epilèpsia en els infants
Models animals en la investigació
Epilepsy in children
Animal models in research
|Abstract:||Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Δ9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Δ9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines.|
|Note:||Reproducció del document publicat a: https://doi.org/10.3389/fphar.2016.00359|
|It is part of:||Frontiers in Pharmacology, 2016, vol. 7, p. 359|
|Appears in Collections:||Articles publicats en revistes (Medicina)|
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
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