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http://hdl.handle.net/2445/152137
Title: | Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol |
Author: | Crippa, Jose Alexandre Crippa, Ana C.S. Hallak, Jaime E. C. Martín-Santos Laffon, Rocío Zuardi, Antonio W. |
Keywords: | Cànnabis Epilèpsia en els infants Models animals en la investigació Cannabis Epilepsy in children Animal models in research |
Issue Date: | 30-Sep-2016 |
Publisher: | Frontiers Media |
Abstract: | Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Δ9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Δ9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fphar.2016.00359 |
It is part of: | Frontiers in Pharmacology, 2016, vol. 7, p. 359 |
URI: | http://hdl.handle.net/2445/152137 |
Related resource: | https://doi.org/10.3389/fphar.2016.00359 |
ISSN: | 1663-9812 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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