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Title: Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study
Author: Zumel Marne, Angela
Kundi, Michael
Castaño-Vinyals, Gemma
Alguacil, Juan
Petridou, Eleni Th
Georgakis, Marios K.
Morales Suárez-Varela, María
Sadetzki, Siegal
Piro, Sara
Nagrani, Rajini
Filippini, Graziella
Hutter, Hans‑Peter
Dikshit, Rajesh
Woehrer, Adelheid
Maule, Milena
Weinmann, Tobias
Krewski, Daniel
Mannetje, Andrea 't
Momoli, Franco
Lacour, Brigitte
Mattioli, Stefano
Spinelli, John J.
Ritvo, Paul
Remen, Thomas
Kojimahara, Noriko
Eng, Amanda
Thurston, Angela
Lim, Hyungryul
Ha, Mina
Yamaguchi, Naohito
Mohipp, Charmaine
Bouka, Evdoxia
Eastman, Chelsea
Vermeulen, Roel C. H.
Kromhout, Hans
Cardis, Elisabeth
Keywords: Tumors cerebrals
Brain tumors
Issue Date: 3-Mar-2020
Publisher: Springer Verlag
Abstract: Introduction: We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutof of 50%, with a joint occurrence of 67%. Overall, the median time from frst symptom to diagnosis was 1.42 months (IQR0.53–4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identifed, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
Note: Reproducció del document publicat a:
It is part of: Journal of Neuro-Oncology, 2020
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ISSN: 0167-594X
Appears in Collections:Articles publicats en revistes (ISGlobal)

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