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Title: Alkynyl gold(I) phosphane complexes: evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex
Author: Andermark, Vincent
Göke, Katrin
Kokoschka, Malte
Abu el Maaty, Mohamed
Lumg, Chin Tung
Zoug, Taotao
Sun, Raymond Wai-Tin
Aguiló Linares, Elisabet
Oehninger, Luciano
Rodríguez Raurell, Laura
Bunjes, Heike
Wölflf, Stefan
Cheg, Chi-Ming
Ott, Ingo
Keywords: Càncer
Protein microarrays
Issue Date: 20-Dec-2015
Publisher: Springer Verlag
Abstract: The synthesis and characterization of four organometallic gold(I) complexes containing different water soluble phosphanes (TPPTS, PTA and DAPTA) and chromophoric units (4-pyridylethynyl and propargyloxycoumarin) is here reported. The analysis of their absorption and emission spectra led us to attribute their luminescent behaviour to the chromophoric organic ligands. Moreover, the presence of the gold(I) metal atom has been observed to be the responsible of an efficient intersystem crossing process responsible for the observed phosphorescence emission. Broad emission bands are observed in most cases due to the formation of organized aggregates in solution in agreement with microscopic characterization. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR). The missing / low cytotoxic effects could be related to a low bioavailability as determined by atomic absorption spectroscopy.
Note: Versió postprint del document publicat a:
It is part of: Journal of Biological Inorganic Chemistry, 2015, vol. 160, p. 140-148
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ISSN: 0949-8257
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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