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Title: 'Head-to-side-chain' cyclodepsipeptides of marine origin
Author: Pelay Gimeno, Marta
Tulla-Puche, Judit
Albericio Palomera, Fernando
Keywords: Productes naturals
Medicaments peptídics
Natural products
Peptide drugs
Issue Date: 21-May-2013
Publisher: MDPI
Abstract: Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as "head-to-side-chain" cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
Note: Reproducció del document publicat a:
It is part of: Marine Drugs, 2013, vol. 11, num. 5, p. 1693-1717
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ISSN: 1660-3397
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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