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Title: | Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione |
Author: | Rodríguez Cabrera, Hortensia María Martin, Osnieski Suárez, Margarita Martín, Nazario Albericio Palomera, Fernando |
Keywords: | Escalfament per microones Molècules Química verda Calefacció Microwave heating Molecules Green chemistry Heating |
Issue Date: | 21-Nov-2011 |
Publisher: | MDPI |
Abstract: | Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules16119620 |
It is part of: | Molecules, 2011, vol. 16, num. 11, p. 9620-9635 |
URI: | http://hdl.handle.net/2445/152588 |
Related resource: | https://doi.org/10.3390/molecules16119620 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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