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Title: Impact of adaptive thermogenesis in mice on the treatment of obesity
Author: Bastías-Pérez, Marianela
Zagmutt Caroxa, Sebastián
Soler Vázquez, M. Carmen
Serra i Cucurull, Dolors
Mera Nanín, Paula
Herrero Rodríguez, Laura
Keywords: Obesitat
Teixit adipós
Metabolisme basal
Temperatura corporal
Adipose tissues
Basal metabolism
Body temperature
Issue Date: 28-Jan-2020
Abstract: Obesity and associated metabolic diseases have become a priority area of study due to the exponential increase in their prevalence and the corresponding health and economic impact. In the last decade, brown adipose tissue has become an attractive target to treat obesity. However, environmental variables such as temperature and the dynamics of energy expenditure could influence brown adipose tissue activity. Currently, most metabolic studies are carried out at a room temperature of 21ºC, which is considered a thermoneutral zone for adult humans. However, in mice this chronic cold temperature triggers an increase in their adaptive thermogenesis. In this review, we aim to cover important aspects related to the adaptation of animals to room temperature, the influence of housing and temperature on the development of metabolic phenotypes in experimental mice and their translation to human physiology. Mice studies performed in chronic cold or thermoneutral conditions allow us to better understand underlying physiological mechanisms for successful, reproducible translation into humans in the fight against obesity and metabolic diseases.
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It is part of: Cells, 2020, vol. 9, num. 316
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ISSN: 2073-4409
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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