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Title: Synthesis of 2-(4,6-dimethyoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis
Author: Al-Warhi, Tarfah I.
AL-Hazimi, Hassan M.A.
El-Faham, Ayman
Albericio Palomera, Fernando
Keywords: Síntesi de pèptids
Àcids carboxílics
Minerals d'urani
Peptide synthesis
Carboxylic acids
Uranium ores
Issue Date: 20-Dec-2010
Publisher: MDPI
Abstract: A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gave the corresponding N-triazinyl amino acid derivatives as a major product. The oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) uronium salt was superior to other uronium salts in terms of racemization, while 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT, 9) gave the best results.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2010, vol. 15, num. 12, p. 9403-9417
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ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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