Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/152818
Title: | Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA |
Author: | Alguacil, Javier Robles i Brau, Jordi Ràfols Llach, Clara Bosch, Elisabeth |
Keywords: | Calorimetria Antibiòtics RNA Termodinàmica Calorimetry Antibiotics RNA Thermodynamics |
Issue Date: | 2016 |
Publisher: | John Wiley & Sons |
Abstract: | Isothermal titration calorimetry (ITC) is a powerful technique able to evaluate the energetics of target-drug binding within the context of drug discovery. In this work, the interactions of RNAs reproducing bacterial and human ribosomal A-site, with two well-known antibiotic aminoglycosides, Paromomycin and Neomycin, as well as several Neomycin-dinucleotide and -diPNA conjugates, have been evaluated by ITC and the corresponding thermodynamic quantities determined. The comparison of the thermodynamic data of aminoglycosides and their chemical analogues allowed to select Neomycin-diPNA conjugates as the best candidates for antimicrobial activity. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/jmr.2513 |
It is part of: | Journal of Molecular Recognition, 2016, vol. 29, num. 4, p. 142-150 |
URI: | http://hdl.handle.net/2445/152818 |
Related resource: | https://doi.org/10.1002/jmr.2513 |
ISSN: | 0952-3499 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
656691.pdf | 195.51 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.