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Title: MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
Author: Migliori, Giovanni Battista
Tiberi, Simon
Zumla, Alimuddin
Petersen, Eskild
Muhwa Chakaya, Jeremiah
Wejse, Christian
Muñoz Torrico, Marcela
Duarte, Raquel
Alffenaar, Jan-Willem
Schaaf, H. Simon
Marais, Ben J.
Cirillo, Daniela Maria
Alagna, Riccardo
Rendon, Adrian
Pontali, Emanuele
Piubello, Alberto
Figueroa, José
Ferlazzo, Gabriella
García-Basteiro, Alberto L.
Centis, Rosella
Visca, Dina
Ambrosio, Lia D’
Sotgiu, Giovanni
Global Tuberculosis Network
Keywords: Tuberculosi
Issue Date: 1-Mar-2020
Publisher: Elsevier
Abstract: The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
Note: Reproducció del document publicat a:
It is part of: International Journal of Infectious Diseases, 2020, vol. 92, p. S15-S25
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ISSN: 1201-9712
Appears in Collections:Articles publicats en revistes (ISGlobal)

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