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Title: Aggregation induced emission of a new naphthyridine-ethynyl-gold(I) complex as a potential tool for sensing guanosine nucleotides in aqueous media
Author: Moro, Artur J.
Avó, João
Malfois, Marc
Zaccaria, Francesco
Fonseca Guerra, Célia
Caparrós Rodríguez, Francisco Javier
Rodríguez Raurell, Laura
Lima, João Carlos
Keywords: Or
Compostos d'or
Gold compounds
Issue Date: 7-Jan-2020
Publisher: Royal Society of Chemistry
Abstract: A new organometallic alkynyl-gold(I) complex, capable of exhibiting Aggregation Induced Emission was designed and synthesized. The linear complex structure possesses a central Au(I) atom, bearing two axial ligands: (1) 1,3,5-Triaza-7-phosphaadamantane; and (2) 2- acetamido-7-ethynyl-1,8-naphthyridine. While the former accounts for its partial solubility in aqueous environment, the latter acts as a receptor unit for binding guanosine nucleotides and derivatives via multiple hydrogen bonding. At high concentrations, aggregation of the complex was observed by the formation of new absorption (λmax ~ 400 nm) and emission bands (550-700 nm). Formation of aggregates of ca. 60 nm diameter was confirmed with Small Angle X-Ray Scattering (SAXS). Disruption of the aggregates in the presence of guanosine derivatives resulted in a ratiometric signal with apparent association constants in the order of 105 M-1 and high sensitivity (around 63% signal change) which are, to the best of our knowledge, in line with the highest recorded for nucleotide sensing based on hydrogen bonding that are capable of working in water. Computational studies indicate the presence of additional hydrogen bonding interactions that account for the strong binding of the Au(I) complex to phosphorylated Guanosine nucleotides.
Note: Versió postprint del document publicat a:
It is part of: Dalton Transactions, 2020, vol. 49, num. 1, p. 171-178
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ISSN: 1477-9226
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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