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Title: Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents
Author: Caro, Carlos
Dalmases Solé, Mariona
Figuerola i Silvestre, Albert
García-Martín, M.L.
Pernia Leal, Manuel
Keywords: Lligands
Issue Date: 25-Apr-2017
Publisher: Royal Society of Chemistry
Abstract: X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging.
Note: Versió postprint del document publicat a:
It is part of: Nanoscale, 2017, vol. 9, num. 21, p. 7242-7251
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ISSN: 2040-3364
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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