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http://hdl.handle.net/2445/154912
Title: | Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents |
Author: | Caro, Carlos Dalmases Solé, Mariona Figuerola i Silvestre, Albert García-Martín, M.L. Pernia Leal, Manuel |
Keywords: | Lligands Nanopartícules Tomografia Ligands Nanoparticles Tomography |
Issue Date: | 25-Apr-2017 |
Publisher: | Royal Society of Chemistry |
Abstract: | X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1039/C7NR01110E |
It is part of: | Nanoscale, 2017, vol. 9, num. 21, p. 7242-7251 |
URI: | http://hdl.handle.net/2445/154912 |
Related resource: | https://doi.org/10.1039/C7NR01110E |
ISSN: | 2040-3364 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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679907.pdf | 1.22 MB | Adobe PDF | View/Open |
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