Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/154913
Title: Lipid alterations in lipid rafts from alzheimer's disease human brain cortex
Author: Martín, Virginia
Fabelo, Noemí
Santpere Baró, Gabriel
Puig Martorell, Berta
Marín, Raquel
Ferrer, Isidro (Ferrer Abizanda)
Díaz, Mario
Keywords: Lípids
Escorça cerebral
Malaltia d'Alzheimer
Lipids
Cerebral cortex
Alzheimer's disease
Issue Date: 2010
Publisher: IOS Press
Abstract: Lipid rafts are membrane microdomains intimately associated with cell signaling. These biochemical microstructures are characterized by their high contents of sphingolipids, cholesterol and saturated fatty acids and a reduced content of polyunsaturated fatty acids (PUFA). Here, we have purified lipid rafts of human frontal brain cortex from normal and Alzheimer's disease (AD) and characterized their biochemical lipid composition. The results revealed that lipid rafts from AD brains exhibit aberrant lipid profiles compared to healthy brains. In particular, lipid rafts from AD brains displayed abnormally low levels of n-3 long chain polyunsaturated fatty acids (LCPUFA, mainly 22:6n-3, docosahexaenoic acid) and monoenes (mainly 18:1n-9, oleic acid), as well as reduced unsaturation and peroxidability indexes. Also, multiple relationships between phospholipids and fatty acids were altered in AD lipid rafts. Importantly, no changes were observed in the mole percentage of lipid classes and fatty acids in rafts from normal brains throughout the lifespan (24-85 years). These indications point to the existence of homeostatic mechanisms preserving lipid raft status in normal frontal cortex. The disruption of such mechanisms in AD brains leads to a considerable increase in lipid raft order and viscosity, which may explain the alterations in lipid raft signaling observed in AD.
Note: Reproducció del document publicat a: https://doi.org/10.3233/JAD-2010-1242
It is part of: Journal of Alzheimer's Disease, 2010, vol. 19, num. 2, p. 489-502
URI: http://hdl.handle.net/2445/154913
Related resource: https://doi.org/10.3233/JAD-2010-1242
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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