Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/155311
Title: | Investigation of the N-terminus amino functional of Arg10-Teixobactin |
Author: | Abdel Monaim, Shimaa A. H. Noki, Sikabwe Ramchuran, Estelle J. El-Faham, Ayman Albericio Palomera, Fernando de la Torre, Beatriz G. |
Keywords: | Síntesi de pèptids Bacteris Mycobacterium tuberculosis Peptide synthesis Bacteria Mycobacterium tuberculosis |
Issue Date: | 28-Sep-2017 |
Publisher: | MDPI |
Abstract: | Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules22101632 |
It is part of: | Molecules, 2017, vol. 22, num. 10, p. 1632 |
URI: | http://hdl.handle.net/2445/155311 |
Related resource: | https://doi.org/10.3390/molecules22101632 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
681058.pdf | 711.58 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License