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http://hdl.handle.net/2445/155518
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DC Field | Value | Language |
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dc.contributor.author | Fernández-Vega, Iván | - |
dc.contributor.author | Diaz-Lucena, Daniela | - |
dc.contributor.author | Azkune Calle, Itxaso | - |
dc.contributor.author | Geijo, Maria | - |
dc.contributor.author | Juste, Ramón A. | - |
dc.contributor.author | Llorens Torres, Franc | - |
dc.contributor.author | Vicente Etxenausia, Ikerne | - |
dc.contributor.author | Santos-Juanes, Jorge | - |
dc.contributor.author | Zarranz, Juan J. | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.date.accessioned | 2020-04-16T10:21:04Z | - |
dc.date.available | 2020-04-16T10:21:04Z | - |
dc.date.issued | 2018-10-01 | - |
dc.identifier.issn | 0919-6544 | - |
dc.identifier.uri | http://hdl.handle.net/2445/155518 | - |
dc.description.abstract | Proteinase K-resistant prion protein (PrPRes ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases. Keywords: Creutzfeldt-Jakob disease; astrocytes; oligodendrocytes; prion. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/neup.12505 | - |
dc.relation.ispartof | Neuropathology, 2018, vol. 38, num. 5, p. 561-567 | - |
dc.relation.uri | https://doi.org/10.1111/neup.12505 | - |
dc.rights | (c) Japanese Society of Neuropathology, 2018 | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Malaltia de Creutzfeldt-Jakob | - |
dc.subject.classification | Neuròglia | - |
dc.subject.classification | Prions | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Patologia | - |
dc.subject.other | Creutzfeldt-Jakob disease | - |
dc.subject.other | Neuroglia | - |
dc.subject.other | Prions | - |
dc.subject.other | Proteins | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Pathology | - |
dc.title | Sporadic Creutzfeldt-Jakob disease with glial PrPRes nuclear and perinuclear immunoreactivity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 689454 | - |
dc.date.updated | 2020-04-16T10:21:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30123962 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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689454.pdf | 910.64 kB | Adobe PDF | View/Open |
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