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Title: Writers, readers and erasers of RNA modifications in cancer
Author: Esteve-Puig, Rosaura
Bueno Costa, Alberto
Esteller, Manel
Keywords: Epigenètica
Issue Date: 1-Apr-2020
Publisher: Elsevier B.V.
Abstract: Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone modifications. Very recently, a third component has emerged: the so-called epitranscriptome understood as the chemical modifications of RNA that regulate and alter the activity of RNA molecules. In this regard, the study of genetic and epigenetic disruption of the RNA-modifying proteins is gaining momentum in advancing our understanding of cancer biology. Furthermore, the development of epitranscriptomic anticancer drugs could lead to new promising and unexpected therapeutic strategies for oncology in the coming years.
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It is part of: Cancer Letters, 2020, vol. 474, p. 127-137
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ISSN: 0304-3835
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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