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Title: Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
Author: Arpón, Ana
Milagro, Fermín I.
Razquin, Cristina
Corella Piquer, Dolores
Estruch Riba, Ramon
Fitó Colomer, Montserrat
Martí, Amelia
Martínez-González, Miguel Ángel, 1957-
Ros Rahola, Emilio
Salas Salvadó, Jordi
Riezu-Boj, José-Ignacio
Martínez, J. Alfredo, 1957-
Keywords: Cuina mediterrània
Cuina (Fruita seca)
Oli d'oliva
Cèl·lules sanguínies
Mediterranean cooking
Cooking (Dried foods)
Olive oil
Blood cells
Issue Date: 23-Dec-2017
Publisher: MDPI
Abstract: DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group. Methylation was assessed at baseline and at five-year follow-up. Ingenuity pathway analysis showed routes with differentially methylated CpG sites (CpGs) related to intermediate metabolism, diabetes, inflammation, and signal transduction. Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism. Furthermore, cg01081346 was associated with PUFAs intake, showing a role for specific fatty acids on epigenetic modulation. Specific components of MedDiet, particularly nuts and EVOO, were able to induce methylation changes in several PWBCs genes. These changes may have potential benefits in health; especially those changes in genes related to intermediate metabolism, diabetes, inflammation and signal transduction, which may contribute to explain the role of MedDiet and fat quality on health outcomes.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2017, vol. 10, num. 1, p. 15
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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