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http://hdl.handle.net/2445/156079
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DC Field | Value | Language |
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dc.contributor.author | Piqué, Laia | - |
dc.contributor.author | Martínez de Paz, Alexia | - |
dc.contributor.author | Piñeyro, David | - |
dc.contributor.author | Martínez Cardús, Anna | - |
dc.contributor.author | Castro de Moura, Manuel | - |
dc.contributor.author | Llinàs-Arias, Pere | - |
dc.contributor.author | Setién, Fernando | - |
dc.contributor.author | Gómez Miragaya, Jorge | - |
dc.contributor.author | González Suárez, Eva | - |
dc.contributor.author | Sigurdsson, Stefan | - |
dc.contributor.author | Jonasson, Jon G. | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.contributor.author | Vidal-Bel, August | - |
dc.contributor.author | Davalos, Veronica | - |
dc.contributor.author | Esteller, Manel | - |
dc.date.accessioned | 2020-04-20T13:45:10Z | - |
dc.date.available | 2020-04-20T13:45:10Z | - |
dc.date.issued | 2019-11-01 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | http://hdl.handle.net/2445/156079 | - |
dc.description.abstract | Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated factors have been described in some cases, almost nothing is known about the contribution of distorted epigenetic patterns to aberrant splicing. Herein, we show that the splicing RNA-binding protein CELF2 is targeted by promoter hypermethylation-associated transcriptional silencing in human cancer. Focusing on the context of breast cancer, we also demonstrate that CELF2 restoration has growth-inhibitory effects and that its epigenetic loss induces an aberrant downstream pattern of alternative splicing, affecting key genes in breast cancer biology such as the autophagy factor ULK1 and the apoptotic protein CARD10. Furthermore, the presence of CELF2 hypermethylation in the clinical setting is associated with shorter overall survival of the breast cancer patients carrying this epigenetic lesion. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Macmillan Publishers | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41388-019-0936-x | - |
dc.relation.ispartof | Oncogene, 2019, vol. 38, num. 45, p. 7106-7112 | - |
dc.relation.uri | https://doi.org/10.1038/s41388-019-0936-x | - |
dc.rights | cc-by (c) Piqué et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Teixit nerviós | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Metilació | - |
dc.subject.classification | RNA | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Proteins | - |
dc.subject.other | Nerve tissue | - |
dc.subject.other | DNA | - |
dc.subject.other | Methylation | - |
dc.subject.other | RNA | - |
dc.title | Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 694462 | - |
dc.date.updated | 2020-04-20T13:45:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31409895 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Fisiològiques) |
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694462.pdf | 979.47 kB | Adobe PDF | View/Open |
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