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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/156117
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dc.contributor.authorRovira, Xavier-
dc.contributor.authorTrapero, Ana-
dc.contributor.authorPittolo, Silvia-
dc.contributor.authorZussy, Charleine-
dc.contributor.authorFaucherre, Adèle-
dc.contributor.authorJopling, Chris-
dc.contributor.authorGiraldo, Jesús-
dc.contributor.authorPin, Jean-Philippe-
dc.contributor.authorGorostiza Langa, Pablo Ignacio-
dc.contributor.authorGoudet, Cyril-
dc.contributor.authorLlebaria Soldevila, Amadeu-
dc.date.accessioned2020-04-20T16:06:02Z-
dc.date.available2020-04-20T16:06:02Z-
dc.date.issued2016-08-18-
dc.identifier.urihttp://hdl.handle.net/2445/156117-
dc.description.abstractOptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.ca
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengca
dc.publisherElsevier-
dc.relation.ispartofCell Chemical Biology, 2016, vol. 23, num. 8 p. 929-934-
dc.relation.urihttps://doi.org/10.1016/j.chembiol.2016.06.013-
dc.rightscc by-nc-nd (c) Elsevier, 2016-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))-
dc.subject.classificationSistema nerviós-
dc.subject.classificationDolor crònic-
dc.subject.otherNervous system-
dc.subject.otherChronic pain-
dc.titleOptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activityca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/785907/EU//HBP_SGA2ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/270483/EU//FOCUS-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/335011/EU//THERALIGHT-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/210355/EU//OPTICALBULLET-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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