Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/156462
Title: N-oxide alkaloids from Crinum amabile (Amaryllidaceae)
Author: Ruschel Tallini, Luciana
Torras Claveria, Laura
Borges, Warley de Souza
Kaiser, Marcel
Viladomat Meya, Francesc
Zuanazzi, José Angelo S.
Bastida Armengol, Jaume
Keywords: Productes naturals
Medicaments
Amaril·lidàcies
Natural products
Drugs
Amaryllidaceae
Issue Date: 26-May-2018
Publisher: MDPI
Abstract: Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.
Note: Reproducció del document publicat a: https://doi.org/10.3390/molecules23061277
It is part of: Molecules, 2018, vol. 23, num. 6, p. 1277
URI: http://hdl.handle.net/2445/156462
Related resource: https://doi.org/10.3390/molecules23061277
ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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