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Title: | Kororamides, convolutamines, and indole derivatives as possible tau and dual specificity kinases inhibitors for Alzheimer's Disease |
Author: | Llorach Parés, Laura Nonell Canals, Alfons Sánchez Martínez, Melchor Avila, Conxita |
Keywords: | Malaltia d'Alzheimer Disseny de medicaments Alzheimer's disease Drug design |
Issue Date: | 16-Oct-2018 |
Publisher: | MDPI |
Abstract: | Alzheimer's disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing. Actual treatments for AD produce only a modest amelioration of symptoms, although there is a constant ongoing research of new therapeutic strategies oriented to improve the amelioration of the symptoms, and even to completely cure the disease. A principal feature of AD is the presence of neurofibrillary tangles (NFT) induced by the aberrant phosphorylation of the microtubule-associated protein tau in the brains of affected individuals. Glycogen synthetase kinase-3 beta (GSK3β), casein kinase 1 delta (CK1δ), dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) and dual-specificity kinase cdc2-like kinase 1 (CLK1) have been identified as the principal proteins involved in this process. Due to this, the inhibition of these kinases has been proposed as a plausible therapeutic strategy to fight AD. In this study, we tested in silico the inhibitory activity of different marine natural compounds, as well as newly-designed molecules from some of them, over the mentioned protein kinases, finding some new possible inhibitors with potential therapeutic application. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/md16100386 |
It is part of: | Marine Drugs, 2018, vol. 16, num. 10, p. 386 |
URI: | http://hdl.handle.net/2445/156538 |
Related resource: | https://doi.org/10.3390/md16100386 |
ISSN: | 1660-3397 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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