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Title: Lifetime psychotic symptoms, subthreshold depression and cognitive impairment as barriers to functional recovery in patients with bipolar disorder
Author: Bonnín, Caterina del Mar
Jiménez Martínez, Ester
Solé, Brisa
Torrent, Carla
Radua, Joaquim
Reinares, Maria
Grande i Fullana, Iria
Ruíz, Victoria
Sánchez-Moreno, José
Martínez-Arán, Anabel, 1971-
Vieta i Pascual, Eduard, 1963-
Keywords: Trastorn bipolar
Malalts crònics
Psicologia social
Depressió psíquica
Manic-depressive illness
Chronically ill
Social psychology
Mental depression
Issue Date: 18-Jul-2019
Publisher: MDPI
Abstract: Background: bipolar disorder (BD) is a chronic disease that often leads to functional impairment. The objective of this study is to elucidate which variables are associated with better functional outcomes in a sample of euthymic patients with BD. (2) Methods: patients were recruited at the Hospital Clinic of Barcelona and they underwent a clinical interview, a functional assessment, and a comprehensive neuropsychological evaluation. After that, patients were divided into two groups according to the Functioning Assessment Short Test total score: functionally remitted vs. functionally impaired. Following this, a multivariate logistic regression was run in order to identify clinical, demographic and cognitive factors associated with functional remission. (3) Results: a total of 420 euthymic patients with BD were assessed for this study, distributed as follows: functionally remitted (n = 221) and functionally impaired (n = 199). Finally, the multivariate logistic regression revealed that only five variables significantly contributed to the model, including: lifetime history of psychotic symptoms (the variable that contributed the most to the model), followed by the Hamilton Depression total score, and cognitive performance (executive functions and verbal memory). (4) Conclusions: treatments to ensure a good functional outcome in BD should specially prevent psychosis, target subthreshold depressive symptoms and enhance cognition, more specifically executive functions and verbal memory.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2019, vol. 8, num. 7, p. 1046
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Divulgació i Premsa (Psicologia Clínica i Psicobiologia)

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