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Title: Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
Author: Xargay i Torrent, Sílvia
Espuña Capote, Núria
Montesinos Costa, Mercè
Prats Puig, Anna
Carreras Badosa, Gemma
Díaz Roldán, Ferran
Zegher, Francis de
Ibáñez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
Keywords: Malalties cardiovasculars
Factors de risc en les malalties
Malalties dels infants
Cardiovascular diseases
Risk factors in diseases
Children's diseases
Issue Date: 14-Dec-2018
Publisher: Nature Publishing Group
Abstract: Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p < 0.0001), waist circumference (p < 0.0001), SBP (p < 0.0001), cIMT (p = 0.005), HOMA-IR (p < 0.0001), and fasting triglycerides (p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p < 0.0001), SBP (r = 0.324; p < 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291; p < 0.0001)]. ALP independently associated with SBP (β = 0.290, p < 0.001) and cIMT (β = 0.179, p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.
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It is part of: Scientific Reports, 2018, vol. 8, num. 1, p. 17864
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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