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http://hdl.handle.net/2445/156819
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DC Field | Value | Language |
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dc.contributor.author | Fullana, Miquel A. | - |
dc.contributor.author | Zhu, Xi | - |
dc.contributor.author | Alonso Ortega, María del Pino | - |
dc.contributor.author | Cardoner, N. (Narcís) | - |
dc.contributor.author | Real, Eva | - |
dc.contributor.author | López Solà, Clara | - |
dc.contributor.author | Segalàs Cosi, Cinto | - |
dc.contributor.author | Subirà Coromina, Marta | - |
dc.contributor.author | Galfalvy, Hanga | - |
dc.contributor.author | Menchón Magriñá, José Manuel | - |
dc.contributor.author | Simpson, H. Blair | - |
dc.contributor.author | Marsh, Rachel | - |
dc.contributor.author | Soriano Mas, Carles | - |
dc.date.accessioned | 2020-04-22T11:24:41Z | - |
dc.date.available | 2020-04-22T11:24:41Z | - |
dc.date.issued | 2017-11-01 | - |
dc.identifier.issn | 1180-4882 | - |
dc.identifier.uri | http://hdl.handle.net/2445/156819 | - |
dc.description.abstract | Background: cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. Methods: we investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD. We assessed BLA-vmPFC rs-fc in patients with OCD on a stable dose of a selective serotonin reuptake inhibitor who then received CBT and in healthy control participants. Results: we included 73 patients with OCD and 84 healthy controls in our study. Decreased BLA-vmPFC rs-fc predicted a better CBT outcome in patients with OCD and was also detected in those with OCD compared with healthy participants. Additional analyses revealed that decreased BLA-vmPFC rs-fc uniquely characterized the patients with OCD who responded to CBT. Limitations: we used a sample of convenience, and all patients were receiving pharmacological treatment for OCD. Conclusion: in this large sample of patients with OCD, BLA-vmPFC functional connectivity predicted CBT outcome. These results suggest that future research should investigate the potential of BLA-vmPFC pathways to inform treatment selection for CBT across patients with OCD and anxiety disorders. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Canadian Medical Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1503/jpn.160215 | - |
dc.relation.ispartof | Journal of Psychiatry & Neuroscience, 2017, vol. 42, num. 6, p. 378-385 | - |
dc.relation.uri | https://doi.org/10.1503/jpn.160215 | - |
dc.rights | (c) Fullana, Miquel A. et al., 2017 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Diagnòstic per la imatge | - |
dc.subject.classification | Teràpia cognitiva | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Neurosi obsessiva | - |
dc.subject.classification | Escorça frontal | - |
dc.subject.other | Diagnostic imaging | - |
dc.subject.other | Cognitive therapy | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Obsessive-compulsive disorder | - |
dc.subject.other | Prefrontal cortex | - |
dc.title | Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687037 | - |
dc.date.updated | 2020-04-22T11:24:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28632120 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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687037.pdf | 587.91 kB | Adobe PDF | View/Open |
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