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Title: Basal Ventricular Septal Hypertrophy in Systemic Hypertension
Author: Loncaric, Filip
Nunno, Loredana
Mimbrero, Maria
Marciniak, Maciej
Fernandes, Joao Filipe
Tirapu, Laia
Fabijanovic, Dora
Sanchis Ruiz, Laura
Doltra, Adelina
Cikes, Maja
Lamata, Pablo
Bijnens, Bart
Sitges Carreño, Marta
Keywords: Hipertensió
Dilatació del cor
Enlargement of the heart
Issue Date: 1-May-2020
Publisher: Elsevier
Abstract: Basal septal hypertrophy (BSH) is commonly seen in patients with systemic hypertension and has been associated with increased afterload. The impact of localized hypertrophy on left ventricular (LV) and left atrial (LA) function is still unclear. Our aim is to investigate if BSH is a marker of a more pronounced impact of hypertension on cardiac function in the early stages of hypertensive heart disease. An echocardiogram was performed in 163 well-controlled hypertensive patients and 22 healthy individuals. BSH was defined by a basal-to-mid septal thickness ratio ≥1.4. LV dimensions and mass were evaluated. LV global and regional deformation was assessed by 2-dimensional (2D) speckle tracking echocardiography, and LV diastolic function by 2D and Doppler imaging. LA function was evaluated with phasic volume indices calculated from 2D and 3-dimensional volumes, as well as speckle tracking echocardiography. The population was 54% men, mean age 57 (53 to 60) years. BSH was seen in 20% (n = 32) of the hypertensive cohort. Patients with BSH showed decreased regional LV systolic deformation, impaired LV relaxation with a higher proportion of indeterminate LV diastolic function, and LA functional impairment defined by a reduction of reservoir strain and a change in LA functional dynamics. In conclusion, in well-controlled hypertension impairment of LV and LA function is present in patients with early LV remodeling and localized hypertrophy. BSH might be useful as an early marker of the burden of hypertensive heart disease.
Note: Versió postprint del document publicat a:
It is part of: The American Journal of Cardiology, 2020, vol. 125, num. 9, p. 1339-1346
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ISSN: 0002-9149
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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