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Title: Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy
Author: Mensa Pueyo, Josep
Barberán, José
Soriano Viladomiu, Alex
Llinares, Pedro
Marco Reverté, Francesc
Cantón, Rafael
Bou, Germán
González del Castillo, Juan
Maseda, Emilio
Azanza, José Ramón
Pasquau, Juan
Garcia Vidal, Carolina
Reguera, José María
Sousa, Dolores
Gómez, Joaquín
Montejo, Miguel
Borges, Marcio
Torres Martí, Antoni
Álvarez Lerma, Francisco
Salavert, Miguel
Zaragoza, Rafael
Oliver, Antoni
Keywords: Malalties infeccioses
Bacteris gramnegatius
Communicable diseases
Gram-negative bacteria
Issue Date: 23-Feb-2018
Publisher: Sociedad Española de Quimioterapia
Abstract: Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics, mainly mediated by the expression of inducible chromosomic β-lactamases and the production of constitutive or inducible efflux pumps. Apart from this intrinsic resistance, P. aeruginosa possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. The progressive increase in resistance rates in P. aeruginosa has led to the emergence of strains which, based on their degree of resistance to common antibiotics, have been defined as multidrug resistant, extended-resistant and panresistant strains. These strains are increasingly disseminated worldwide, progressively complicating the treatment of P. aeruginosa infections. In this scenario, the objective of the present guidelines was to review and update published evidence for the treatment of patients with acute, invasive and severe infections caused by P. aeruginosa. To this end, mechanisms of intrinsic resistance, factors favoring development of resistance during antibiotic exposure, prevalence of resistance in Spain, classical and recently appeared new antibiotics active against P. aeruginosa, pharmacodynamic principles predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment were reviewed to elaborate recommendations by the panel of experts for empirical and directed treatment of P. aeruginosa invasive infections.
Note: Reproducció del document publicat a:;
It is part of: Revista Espanola de Quimioterapia, 2018, vol. 31, num. 1, p. 78-100
ISSN: 0214-3429
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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