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Title: 14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis
Author: Martínez Yélamos, Antonio
Saiz Hinajeros, Albert
Sánchez del Valle Díaz, Raquel
Casado Ruiz, Virginia
Ramon Torrell, Josep M. (Josep Maria)
Graus Ribas, Francesc
Arbizu Urdiain, Txomin
Keywords: Líquid cefalorraquidi
Esclerosi múltiple
Cerebrospinal fluid
Multiple sclerosis
Protein-tyrosine phosphatase
Issue Date: 28-Aug-2001
Publisher: Lippincott, Williams & Wilkins. Wolters Kluwer Health
Abstract: Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution.
Note: Reproducció del document publicat a:
It is part of: Neurology, 2001, vol. 57, num. 4, p. 722-724
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ISSN: 0028-3878
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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