Please use this identifier to cite or link to this item:
Title: Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
Author: Ramos Vicente, David
Ji, Jie
Gratacòs i Batlle, Esther
Gou, Gemma
Reig Viader, Rita
Luís, Javier
Burguera, Demian
Navas Pérez, Enrique
García Fernández, Jordi
Fuentes Prior, Pablo
Escriva, Hector
Roher Armentia, Nerea
Soto del Cerro, David
Bayés, Àlex
Keywords: Receptors de neurotransmissors
Neurotransmitter receptors
Issue Date: 22-Nov-2018
Publisher: eLife Sciences
Abstract: Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.
Note: Reproducció del document publicat a:
It is part of: eLife, 2018, vol. 7, num. e35774, p. e35774
Related resource:
ISSN: 2050-084X
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

Files in This Item:
File Description SizeFormat 
686974.pdf2.23 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons