Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/157462
Title: Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case-Cohort Study
Author: Yu, Edward
Papandreou, Christopher
Ruiz-Canela, Miguel
Guasch-Ferré, Marta
Clish, Clary B.
Dennis, Courtney
Liang, Liming
Corella Piquer, Dolores
Fitó Colomer, Montserrat
Razquin, Cristina
Lapetra, José
Estruch Riba, Ramon
Ros Rahola, Emilio
Cofán Pujol, Montserrat
Arós, Fernando
Toledo Atucha, Estefanía
Serra Majem, Lluís
Sorlí, José V.
Hu, Frank B.
Martínez-González, Miguel Ángel, 1957-
Salas Salvadó, Jordi
Keywords: Diabetis
Estudi de casos
Triptòfan
Diabetes
Case studies
Tryptophan
Issue Date: 1-Aug-2018
Publisher: Nature Publishing Group
Abstract: BACKGROUND: Metabolites of the tryptophan-kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case-cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS: Plasma metabolite concentrations were quantified via LC-MS for n = 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS: Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio = 1.29; 95% CI, 1.04-1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio = 1.39; 95% CI, 1.09-1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. CONCLUSIONS: Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity.
Note: Reproducció del document publicat a: https://doi.org/10.1373/clinchem.2018.288720
It is part of: Scientific Reports, 2018, vol. 64, num. 8, p. 1211-1220
URI: http://hdl.handle.net/2445/157462
Related resource: https://doi.org/10.1373/clinchem.2018.288720
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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