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http://hdl.handle.net/2445/157462
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DC Field | Value | Language |
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dc.contributor.author | Yu, Edward | - |
dc.contributor.author | Papandreou, Christopher | - |
dc.contributor.author | Ruiz Canela, Miguel | - |
dc.contributor.author | Guasch-Ferré, Marta | - |
dc.contributor.author | Clish, Clary B. | - |
dc.contributor.author | Dennis, Courtney | - |
dc.contributor.author | Liang, Liming | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Razquin, Cristina | - |
dc.contributor.author | Lapetra, José | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Cofán Pujol, Montserrat | - |
dc.contributor.author | Arós, Fernando | - |
dc.contributor.author | Toledo Atucha, Estefanía | - |
dc.contributor.author | Serra Majem, Lluís | - |
dc.contributor.author | Sorlí, José V. | - |
dc.contributor.author | Hu, Frank B. | - |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- | - |
dc.contributor.author | Salas Salvadó, Jordi | - |
dc.date.accessioned | 2020-04-24T15:23:24Z | - |
dc.date.available | 2020-04-24T15:23:24Z | - |
dc.date.issued | 2018-08-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/157462 | - |
dc.description.abstract | BACKGROUND: Metabolites of the tryptophan-kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case-cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS: Plasma metabolite concentrations were quantified via LC-MS for n = 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS: Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio = 1.29; 95% CI, 1.04-1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio = 1.39; 95% CI, 1.09-1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. CONCLUSIONS: Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1373/clinchem.2018.288720 | - |
dc.relation.ispartof | Scientific Reports, 2018, vol. 64, num. 8, p. 1211-1220 | - |
dc.relation.uri | https://doi.org/10.1373/clinchem.2018.288720 | - |
dc.rights | cc-by (c) Yu, Edward et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.classification | Triptòfan | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Case studies | - |
dc.subject.other | Tryptophan | - |
dc.title | Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case-Cohort Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687687 | - |
dc.date.updated | 2020-04-24T15:23:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29884676 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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687687.pdf | 437.74 kB | Adobe PDF | View/Open |
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